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KMID : 0043320120350091583
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Archives of Pharmacal Research
2012 Volume.35 No. 9 p.1583 ~ p.1589
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Inhibition of DNA topoisomerases I and II of compounds from Reynoutria japonica
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Hwangbo Kyoung
Zheng Ming Shan
Kim Young-Jin
Im Jong-Yeop
Lee Chong-Soon
Woo Mi-Hee
Jahng Yurng Dong
Chang Hyun-Wook
Son Jong-Keun
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Abstract
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Three anthraquinones (1, 2 and 4), three stilbenes (5, 6 and 7) and 3,5-dihydroxybenzyl alcohol (3) were isolated from Reynoutria japonica. Their structures were identified as emodin (1), emodin-8-O-β-d-glucoside (2), 3,5-dihydroxybenzyl alcohol (3), citreorosein (4), cis-resveratrol (5), trans-resveratrol (6) and trans-resveratrol-5-O-β-d-glucopyranoside (7) by comparing their physicochemical and spectral data with published data. Compound 3 was isolated for the first time from the Polygonaceae family. Among the purified compounds, 3 showed more potent inhibitory activity against topoisomerase I (IC50: 4 μM) than camptothecin, as the positive control (IC50: 18 μM). Compounds 3, 4, 5, 6 and 7 showed stronger inhibitory activities toward DNA topoisomerase II (IC50: 0.54, 14, 15, 0.77 and 3 μM, respectively) than the positive control, etoposide (IC50: 44 μM). Compounds 1 and 4 displayed weak cytotoxicities against human lung cancer (A549), ovarian cancer (SK-OV-3), human liver hepatoblastoma (HepG2) and colon adenocarcinoma (HT-29) cell lines.
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KEYWORD
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Reynoutria japonica, Polygonaceae, Topoisomerase, Cytotoxicity
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